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    Ambien and Ambien CR (zolpidem)

    Common questions about Ambien and Ambien CR

    Here are answers to some frequently asked questions about Ambien and Ambien CR.

    Are trazodone, Xanax, melatonin, and Benadryl used for sleep?

    Can I take any of them with Ambien or Ambien CR?

    Trazodone, Xanax, melatonin and Benadryl may be used for sleep in certain cases. But it’s not advised to take any of them with Ambien or Ambien CR.

    Trazodone and Xanax are not approved to treat sleep problems, but doctors may prescribe them off-label for this purpose.

    Off-label use is when a drug that’s approved to treat one condition is prescribed to treat a different condition.

    Trazodone isn’t known to interact with Ambien or Ambien CR. However, according to the manufacturer of Ambien or Ambien CR, you should not use either drug with other medications for sleep.

    Taking Xanax in combination with Ambien can increase your risk for side effects,* including next-day side effects and unusual sleep behaviors.

    Melatonin and Benadryl are over-the-counter products that may be used for sleep.

    Melatonin isn’t known t

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